Polynucleotides, Profhilo and Sunekos
Non-surgical procedures restore a youthful appearance
At Perfect Smile Clinic in Sudbury, we provide the latest in cosmetic non-invasive injectable skincare treatments to help pause and slow the signs of ageing.
You can enhance skin elasticity and regain a youthful radiance with our range of bio-stimulating and bio-remodelling treatments. These injectable solutions support hydration, cellular repair and collagen regeneration processes, resulting in improved tissue health and skin appearance.
Plinest® Polynucleotides
What Are Polynucleotides?
Polynucleotides (PN) are advanced, bioregenerative molecules derived from high-purity salmon trout DNA. Backed by decades of clinical research, they are designed to repair, regenerate, and revitalise the skin from within.Polynucleotides stimulate fibroblasts (the cells responsible for producing collagen, elastinand hyaluronic acid), making them ideal for improving skin quality
How Plinest® Works
Plinest® by Mastelli Aesthetic (Italy) is one of the most advanced and clinically proven polynucleotide systems available.
Plinest® helps rejuvenate the skin by stimulating fibroblast activity to boost collagen and elastin, and deeply hydrate and improve skin elasticity. It reduces inflammation and oxidative stress and restores tone, textureand radiance, without adding volume.
Plinest® Key Benefits
- Cellular Repair: Helps heal damaged skin at a deep, cellular level.
- Regeneration: Accelerates natural tissue repair and wound-healing processes.
- Hydration & Elasticity: Improves firmness, hydration, and skin elasticity.
- Soothing & Strengthening: Reduces inflammation and restores the skin barrier.
- Radiance: Enhances overall tone, texture, and natural glow.
Areas That Can Be Treated
Plinest® can be safely used on multiple areas to improve skin quality:
- Face and neck
- Under-eyes
- Décolletage
- Hands
- Scalp / Hair
- Body areas with crepey/ lax skin (arms, abdomen, knees)
Procedure Information
TREATMENT TIME
Typically 30 minutes.
BACK TO WORK
No downtime, mild bumps/swelling settle within 24-48 hours.
RESULTS
Results often develop after 2-3 sessions. Full results typically appear after 6–8 weeks.
ANAESTHETIC
No anaesthetic is required. However numbing cream can be applied.
Plinest® Treatment Options
Plinest® Treatment Options
For dull, dehydrated, ageing, or crepey skin.
- Benefits: Improves tone, hydration, firmness, and elasticity.
- Course: 3–4 sessions, 3–4 weeks apart
- Maintenance: Every 6 months
Plinest® Eye – Periorbital Rejuvenation
Targets dark circles, puffiness, fine lines, and crepey under-eye skin.
- Benefits: Firms, brightens, and refreshes the delicate eye area.
- Course: 3 sessions, 2–3 weeks apart
- Maintenance: Every 6 months
Plinest® Hair – Scalp & Hair Revitalisation
Supports scalp health, strengthens follicles, and helps reduce shedding.
- Benefits: Improves scalp hydration, microcirculation, and hair vitality.
- Course: First course: 4 sessions, 1–2 weeks apart / Second course: 4 sessions, 3 weeks apart
- Maintenance: Every 6 months
Plinest® Newest – Deep Hydration & Structural Repair
A combination of polynucleotides + hyaluronic acid for deeper regeneration.
- Benefits: Improves firmness, hydration, and photo-aged or thinning skin.
- Course: 3 sessions, 3–4 weeks apart sessions, 3 weeks apart
- Maintenance: Every 6 months
Aftercare
To achieve the best results following your polynucleotide treatment:
- Avoid touching the area or applying makeup for 6 hours
- Avoid intense exercise, steam rooms, and saunas for 24 hours
- Mild redness, swelling, or small bumps are normal and settle within 24–48 hours
- Use gentle skincare and SPF
- Avoid other cosmetic treatments in the same area for two weeks
FAQs – Plinest Polynucleotides
Face/Neck: 3–4 sessions every 3–4 weeks
Eyes: 3 sessions every 2–3 weeks
Newest: 3 sessions every 3–4 weeks
Hair/Scalp: 4 + 4 sessions
Maintenance: 1 session every 6 months for all areas.
• Improves skin quality, elasticity, and firmness
• Deeply hydrates and revitalises
• Reduces fine lines, crepiness, and fatigue
• Supports healing and tissue regeneration
• Safe, biocompatible, and natural-looking
• Suitable for face, eyes, hands, scalp, and body
Polynucleotides may not be suitable if you:
• Are pregnant or breastfeeding
• Have an allergy to fish-derived ingredients or hyaluronic acid (HA)
• Have an active skin infection, inflammation, or rash
• Are undergoing severe systemic illness or autoimmune disease
• Are taking anticoagulant medication or have a bleeding disorder
• Are unwell on the day of treatment
Suitability will always be confirmed during consultation.
Important Note
All treatments, recommendations, and treatment plans are subject to the outcome of your consultation. During this appointment, your clinician will assess your facial anatomy, medical history, and aesthetic goals to ensure that any treatment is both appropriate and safe, and that it will achieve the most natural and beneficial result for you. Your clinician will also explain all potential risks clearly and tailor the treatment plan to your individual needs.
Profhilo & Profhilo Structura
What is Profhilo?
Profhilo is an injectable, high-concentration hyaluronic acid skin treatment designed to treat skin laxity, boost hydration, and stimulate collagen and elastin production.
Unlike traditional dermal fillers that add volume to specific areas, Profhilo acts as a ‘moisturiser’ beneath-the-skin, that spreads to improve overall skin quality, firmness, and radiance.
Profhilo
- Profhilo is an award-winning, injectable hyaluronic acid skin booster designed to improve hydration, elasticity, firmness, and overall skin quality. Unlike dermal fillers.
- Profhilo does not create volume — instead, it spreads evenly under the skin to stimulate collagen and elastin, giving a smoother, more luminous, and naturally refreshed appearance.
- Profhilo has been recognised internationally and has won multiple industry awards, including “Product Innovation of the Year”, thanks to its unique ability to rejuvenate the skin safely, effectively, and without changing facial shape.
Profhilo Structura
- ProfhiloStructura is an advanced formulation within the Profhilo range, designed to treat areas where deeper structural support is needed. It helps improve definition, firmness, and lift in areas such as the mid-face, while still maintaining a soft, natural look.
- It is ideal for patients experiencing skin laxity or volume-related sagging, offering subtle support without the use of traditional fillers.
Procedure Information
TREATMENT TIME
Typically 30 minutes.
BACK TO WORK
Same day or next day. Small visible lumps at injection points are normal and usually settle within 24–48 hours
RESULTS
Improvement start approx. 6 weeks after first treatment. Best results become visible approx. one month after your second treatment.
ANAESTHETIC
No anaesthetic is required. However numbing cream can be applied.
Aftercare
To achieve the best results following your Profhilo treatment:
- Avoid touching or applying makeup for 6 hours
- Avoid saunas, steam rooms, and intense exercise for 24 hours
- Mild redness or swelling may occur and subsides within a few days.
- Avoid strenuous physical activity for 24h, as this can increase bruising
- Avoid taking alcohol, ibuprofen for 24h, as they also can increase the risk of bruising and swelling
- Do not rub or massage the bumps from the treatment
- Avoid any facial treatments for up 2 weeks to reduce the risk of complication
FAQs – Profhilo & Profhilo Structura
Profhilo and Profhilo Structura are suitable for:
•Men and women
•All skin types
•Those looking to improve skin texture, hydration, and firmness
•Patients wanting natural-looking rejuvenation without changing their facial structure
A consultation is always required to assess suitability and create a personalised treatment plan.
• Face and neck
• Décolletage
• Back of hands
• Body areas with laxity (e.g., arms, abdomen)
Maintenance: generally, one session every 6 months is recommended.
While both Profhilo and dermal fillers contain hyaluronic acid, they serve completely different purposes:
Profhilo
• A skin booster, not a filler
• Improves hydration, elasticity, and overall skin quality
• Spreads evenly under the skin to stimulate collagen and elastin
• Does not add volume or alter facial shape
• Ideal for crepey, dull, or lax skin
Dermal Fillers
• Used to add or restore volume
• Contour areas such as cheeks, lips, jawline, or chin
• Soften deeper static lines
• Stay in one place to provide structure and shape
In summary, Profhilo enhances skin quality, while dermal fillers enhance facial structure. Many patients benefit from both treatments depending on their goals.
Profhilo is very safe when administered by trained clinicians, but as with any injectable treatment, temporary side effects may occur:
•Bruising
•Redness
•Mild swelling
•Temporary lumps or bumps at injection sites
•Sensitivity or tenderness
•Very rarely, allergic reactions
All risks will be fully discussed during your consultation.
• Autoimmune diseases (e.g., lupus, rheumatoid arthritis)
• Bleeding disorders or anticoagulant use
• Uncontrolled diabetes
• Recent Roaccutane (isotretinoin) use
• Keloid or hypertrophic scarring tendency
• Severe allergies or anaphylaxis history Other Precautions
• Wait after dental work, cosmetic procedures, or vaccinations
• Patients with body dysmorphic or related conditions may require further discussion before treatment.
Profhilo and Profhilo Structura may not be suitable if you are:
• Pregnant or breastfeeding
• Under 18 years old
• Allergic to hyaluronic acid
• Experiencing active skin infections or cold sores • Unwell with cold, flu, or other infections
Important Note
All treatments, recommendations, and treatment plans are subject to the outcome of your consultation. During this appointment, your clinician will assess your facial anatomy, medical history, and aesthetic goals to ensure that any treatment is both appropriate and safe, and that it will achieve the most natural and beneficial result for you. Your clinician will also explain all potential risks clearly and tailor the treatment plan to your individual needs.
Sunekos
What Is Sunekos?
Sunekos is an advanced injectable treatment that combines hyaluronic acid with a unique complex of amino acids. This formulation stimulates the natural production of collagen and elastin, helping to improve skin quality from within.
Sunekos is ideal for treating crepey skin, fine lines, dehydration, loss of elasticity, and early signs of ageing while maintaining a very natural result. It is gentle, bioregenerative, and suitable for delicate areas that are difficult to treat with other injectable options.
What Can Sunekos Treat?
Sunekos is suitable for men and women and all ages and skin types. It can help Individuals concerned with skin quality, texture, hydration, or early ageing and those looking for natural, subtle rejuvenation. Also those who prefer non-volumising treatments. Your suitability will always be assessed during consultation.
Sunekos is especially effective for improving:
- Fine lines and wrinkles
- Crepey or thin skin
- Under-eye hollowness or dark circles
- Loss of elasticity and firmness
- Dehydrated or dull skin
- Early signs of ageing
- Acne scarring or texture issues
Areas that can be treated include:
- Face and neck
- Under-eye area
- Decolletage
- Hands and arms
- Body areas with crepey or lax skin
How Does Sunekos Work?
Unlike fillers, Sunekos does not add volume – it focuses on improving skin quality.Sunekos uses a patented formula of hyaluronic acid + amino acids to:
- Boost collagen and elastin
- Improve skin elasticity
- Restore hydration
- Smooth fine lines
- Improve texture and firmness
- Regenerate the skin over time
Procedure Information
TREATMENT TIME
Typically 30 minutes.
BACK TO WORK
Same day. Some mild swelling or small lumps may be visible temporarily (24-48 hours).
RESULTS
Improvements often visible after the second session. Best results are seen 4–6 weeks after completing the full course. Skin continues to improve as collagen and elastin increases.
ANAESTHETIC
No anaesthetic is required. However numbing cream can be applied.
Aftercare
To achieve the best results following your Sunekostreatment:
- Avoid touching or rubbing the treated area immediately after treatment
- Avoid intense heat (saunas, steam rooms) for 24 hours
- Avoid strenuous exercise for the rest of the day
- Mild bumps or swelling may appear and will settle within 24–48 hours
- Avoid other cosmetic treatments in the same area for two weeks
Your clinician will provide full personalised aftercare guidance.
FAQs – Sunekos
Before your treatment, to support the best experience:
• Come with clean skin (no makeup on treatment areas)
• Avoid alcohol for 24 hours (to reduce bruising risk)
• Avoid strenuous exercise right before your appointment
• Certain medications (e.g., aspirin, ibuprofen) may increase bruising risk
Do not stop prescribed medication unless advised by your doctor
• Let us know about any infections, cold sores, or irritation
Your clinician will advise you personally during consultation.
A full Sunekos treatment typically involves:
• 3-4 sessions, spaced 7–10 days apart
• Maintenance sessions may be recommended every 6 months, depending on your skin needs
• Sunekos builds results gradually, giving a soft, natural improvement over time
Although both Sunekos and Profhilo are injectable skin-quality treatments, they work in different ways and are used for different skin concerns.
Profhilo – Profhilo is a pure hyaluronic acid (HA) skin booster designed to:
• Improve hydration, elasticity, and firmness
• Stimulate collagen and elastin
• Give the skin a smoother, more luminous appearance
• Improve overall skin quality and tightness
It spreads evenly under the skin like a “liquid moisturiser” and does not add volume.
Profhilo is excellent for crepey, lax, or thinning skin, particularly on the face, neck, and hands.
Sunekos – Sunekos combines hyaluronic acid + amino acids, giving it a bioregenerative effect. It is designed to:
• Improve fine lines
• Reduce crepey or thin skin
• Improve under-eye hollowness and dark circles
• Boost hydration and skin texture
• Encourage collagen and elastin production through amino-acid stimulation
Sunekos is especially suitable for delicate areas, including the under-eyes, where many other injectables cannot be used.
In Summary, Profhilo is best for overall skin hydration, elasticity, firmness, and glow whilst Sunekos is best for fine lines, crepey skin, under-eye concerns, and early ageing. Both treatments improve skin quality, but they achieve this in different ways. They are not fillers and do not add volume. Many patients benefit from using both treatments at different times depending on their skin needs
Sunekos may not be suitable if:
• You are pregnant or breastfeeding
• You have an active infection or inflammation in the area
• You are allergic to any ingredients in the product
• You are unwell on the day of treatment
• Your clinician determines the treatment is not appropriate for your goals or skin condition
Suitability is always confirmed during consultation.
Sunekos is very safe when administered by trained clinicians.
Temporary side effects may include:
• Mild swelling
• Redness
• Tiny bumps at injection points
• Slight bruising
• Tenderness
• Rare allergic reactions
All potential risks will be discussed during your consultation.
Important Note
All treatments, recommendations, and treatment plans are subject to the outcome of your consultation. During this appointment, your clinician will assess your facial anatomy, medical history, and aesthetic goals to ensure that any treatment is both appropriate and safe, and that it will achieve the most natural and beneficial result for you. Your clinician will also explain all potential risks clearly and tailor the treatment plan to your individual needs.
